Integrative HealthSolutions

Metabolic & Body Composition Support

PHYSIQ™ — Advanced Metabolic & Body Composition Support

Four investigational peptides. One physician-guided approach to exploring metabolic health, growth hormone signaling, and body composition.

Product
Physiq Blend — Tesamorelin / Ipamorelin / AOD-9604 / MOTS-C
Concentration
2 mg / 2 mg / 2 mg / 2 mg per mL
Vial size
5 mL
Total contents per vial
10 mg of each peptide, 40 mg combined
Request a Physician ConsultationExplore the Four Peptides
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The components

Understanding the Four Peptides

FDA-approved (specific indication)

Tesamorelin

Growth Hormone Signaling

A growth hormone-releasing hormone (GHRH) analog that stimulates pituitary growth hormone secretion and increases IGF-1 signaling.

Research focus

  • Studied for effects on visceral adipose tissue.
  • A specific tesamorelin product is FDA-approved to reduce excess abdominal fat in adults with HIV-associated lipodystrophy.
  • Potential metabolic effects are being investigated in other populations.

Important: Approval of a specific tesamorelin drug does not establish approval of this four-peptide combination or of general weight-loss use.

Investigational

Ipamorelin

Growth Hormone Secretagogue

A synthetic peptide that acts at the growth hormone secretagogue receptor (GHS-R1a).

Research focus

  • Growth hormone release.
  • Endocrine signaling and recovery physiology.
  • Possible effects on body composition.

Important: Evidence demonstrating meaningful long-term body composition or recovery benefits in humans remains limited.

Investigational

AOD-9604

Fat Metabolism Research

A modified fragment of human growth hormone investigated for potential effects on lipid metabolism.

Research focus

  • Lipolysis and lipid metabolism.
  • Body fat regulation.
  • Metabolic signaling.

Important: Human clinical studies have not established reliable, clinically meaningful weight-loss efficacy.

Preclinical / early research

MOTS-C

Mitochondrial Metabolic Signaling

A mitochondria-derived peptide involved in experimental research on metabolic regulation.

Research focus

  • Cellular energy metabolism.
  • AMPK-related signaling.
  • Insulin sensitivity and glucose metabolism.
  • Exercise-related metabolic adaptations.

Important: Much of the mechanistic evidence comes from preclinical studies; human clinical efficacy and long-term safety are not established.

Why Study These Four Peptides Together?

  1. 01

    Tesamorelin

    → GH / IGF-1 signaling

  2. 02

    Ipamorelin

    → GH secretagogue receptor signaling

  3. 03

    AOD-9604

    → Investigational lipid metabolism pathways

  4. 04

    MOTS-C

    → Mitochondrial metabolic signaling

Physiq combines four peptides that have been investigated for different aspects of metabolic and endocrine physiology. Their mechanisms provide a rationale for scientific interest, but the combined formulation has not been demonstrated in controlled human trials to produce additive or synergistic clinical benefits.

A Personalized Approach to Metabolic Health

Our approach starts with a comprehensive physician evaluation. Physiq is one option that may be discussed — it is not a proven or routinely recommended treatment, and many patients are better served by other evidence-based options.

  • Body composition and visceral adiposity assessment.
  • Metabolic markers such as fasting glucose, HbA1c, and insulin when clinically indicated.
  • Lipid and cardiovascular risk assessment.
  • Hormonal evaluation when appropriate.
  • Lifestyle, nutrition, resistance training, and sleep optimization.
  • Review of contraindications, safety concerns, and treatment alternatives.

Related: Healthy aging & longevity therapies · Metabolic & weight management therapies · All therapies · Pharmacy sourcing & safety

What Patients Should Know

  • The four-peptide Physiq combination is not FDA-approved.
  • Safety, effectiveness, dosing, and long-term outcomes of the combination have not been established in adequate human clinical trials.
  • Potential concerns with growth hormone-related therapies include elevated IGF-1, fluid retention, joint symptoms, and altered glucose regulation.
  • Contraindications and precautions may include active malignancy, pregnancy, and certain endocrine or metabolic conditions.
  • A physician consultation does not guarantee that this formulation is available, appropriate, or legally permissible to prescribe or dispense.
  • Preparation by a compounding pharmacy does not make this combination FDA-approved or FDA-verified.

Frequently Asked Questions

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